Testing for gene-environment interaction under exposure misspecification

Mutual Information for Testing Gene-Environment Interaction

Despite current enthusiasm for investigation of gene-gene interactions and gene-environment interactions, the essential issue of how to define and detect gene-environment interactions remains unresolved. In this report, we define gene-environment interactions as a stochastic dependence in the context of the effects of the genetic and environmental risk factors on the cause of phenotypic variati...

Simultaneously testing for marginal genetic association and gene-environment interaction.

In this article, the authors propose to simultaneously test for marginal genetic association and gene-environment interaction to discover single nucleotide polymorphisms that may be involved in gene-environment or gene-treatment interaction. The asymptotic independence of the marginal association estimator and various interaction estimators leads to a simple and flexible way of combining the 2 ...

Bayesian Inconsistency under Misspecification

This is a synopsis of the work underlying the author’s contributed plenary presentation at the Valencia 8 meeting on Bayesian Statistics, held in Benidorm, June 2006. We show that Bayesian inference can be inconsistent under misspecification. Specifically, we exhibit a distribution P ∗, a model M with P ∗ 6∈ M, and a prior Π on M such that the prior puts significant mass on P̃ , the best approxi...

A Gene-Environment Interaction

Background—Particulate air pollution has been associated with cardiovascular mortality and morbidity. Transition metals such as iron bound to the particles may be responsible for those associations. The protein product of the hemochromatosis (HFE) gene modulates uptake of iron and divalent cations from pulmonary sources and reduces their toxicity. Two HFE polymorphisms (C282Y and H63D) associat...

microsomal epoxide hydrolase-1 exon 4 polymorphism and h2s-exposure interaction on the spirometry parameters; interaction of gene-environment